AD/PD™ 2019, Lisbon - Pre-Conference: Neuropathology Session

Pre-Conference Workshop

BASIC NEUROPATHOLOGY OF AGE-ASSOCIATED NEURODEGENERATIVE DISEASES

Pre-Conference Full Day Workshop
Tuesday, March 26, 2019
08:00 -17:00

Pre-registration is required. To register, please click here


Co-Chairs

Irina Alafuzoff, Johannes Attems, Kurt Jellinger, Melissa E Murray, Dietmar Thal

The workshop is intended to provide the participant with an understanding of the basic neuropathological features of age associated neurodegenerative diseases. This will include neuropathological hallmark lesions (e.g., amyloid-β plaques, neuritic plaques, neurofibrillary tangles/ threads, Lewy bodies/ neurites etc.) and an explanation how these lesions are assessed to classify diseases (e.g., neuritic Braak stages, amyloid-β phases, CERAD score, NIA-AA criteria, McKeith Criteria etc.).

By attending this workshop the participant should gain a solid and lasting knowledge about the basics covered (e.g., difference amyloid-β plaques vs neuritic plaques and why this difference matters). It is felt by the workshop organizers that unfortunately many colleagues working in the field often lack such basic knowledge and hence some of the scientific work is considerably flawed at a very basic methodological level (e.g., comparison between CERAD scores and PET amyloid imaging data). Yet, the organizers believe that basic principles of neuropathology in neurodegeneration can be understood by non-neuropathologists and such an understanding should be helpful not only in interpreting neuropathological data but also in the planning and conducting of respective scientific studies.

Of note, the workshop is not intended to showcase most recent neuropathological developments that would be of interest to an audience already familiar with neuropathology. Therefore the workshop should be of interest for students, PhDs and physicians.

Before the workshop (3 to 4 weeks) participants should receive electronic handouts with main topics that will be covered (e.g. staging scoring criteria) and list of selected references.

Most sessions are divided into lecture and practical parts. Lectures will be interactive, i.e. participants are encouraged to ask questions. During practical parts images of (immuno)histological sections will be projected and the lecture content will be applied to neuropathologically assess cases (e.g., lecture covers Braak stages, Braak stages will be assigned to various cases).

Schedule

08:00 Welcome / introduction

Speaker: Johannes Attems (United Kingdom)

08:15 Neuroanatomy

Speaker: Dietmar Thal (Germany)

Lecture: Neuroanatomical basics for the diagnosis of neurodegenerative diseases

8:30 Amyloid

Speaker: Dietmar Thal (Germany)

Lecture: Basics, plaques, CAA, amyloid phases

Practical: state amyloid deposition types (subpial band like, fleecy, diffuse, dense); distinguish between CAA and capCAA, assign amyloid phases.

9:30 Hyperphosphorylated tau

Speaker: Kurt Jellinger (Austria)

Lecture: Basics, tangles/ threads, Braak stages, Primary Age Related Tauopathy (PART)

Practical: Assign Braak stages to cases

10:30 Coffee break

11:00 The neuropathological diagnosis of Alzheimer's disease

Speaker: Kurt Jellinger (Austria)

Lecture: CERAD scores, NIA-AA

Practical: Assign NIA-AA score to cases

12:00 Lewy body diseases

Speaker: Irina Alafuzoff (Sweden)

Lecture: Basics, lewy bodies/neurites, McKeith/ Braak a-syn stages, concept Lewy body diseases (dementia with Lewy bodies, Parkinson's dementia, Parkinson's disease)

Practical: assign McKeith/ Braak a-syn stages

12:45 Lunch Break

14:00 Cerebrovascular pathology

Speaker: Dietmar Thal (Germany)

Lecture: examples for cerebrovascular pathology e.g. large and small vessel disease, hemorrhage, infarcts

Practical: state severity of atherosclerosis, SVD, white matter pallor, deep gray matter lesions, distinguish fresh/ old infarct

14:45 TDP-43

Speaker: Irina Alafuzoff (Sweden)

Lecture only: brief overview of TDP-43 proteinopathies

15:00 Multimorbidity of the "old" human brain (overlap of pathologies)

Speaker: Johannes Attems (United Kingdom)

Lecture: recapitulate morning (staging), emphasize high co-occurrence of pathologies (ie multimorbdidity) incl findings from large autopsy studies. Discuss TDP-43 in AD.

Practical: give NIA-AA, McKeith to mixed cases, spot TDP-43.

15:30 Coffee break

15:45 Clinico-pathological correlative studies and neurodegeneration

Speaker: Melissa E Murray (United States of America)

Lecture only: Role of post-mortem neuropathological examination as quality control/ feedback for the clinician (clinical diagnosis, drug trials).

16:15 Neuropathological examination of various cases

Practical only

17:00 End